Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium

The fetal intestinal mucosa is characterized by elevated Toll-like receptor 4 (TLR4) expression, which can lead to the development of necrotizing enterocolitis (NEC)—a devastating inflammatory disease of the premature intestine—upon exposure to microbes. To define endogenous strategies that could re...

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Hlavní autoři: Good, Misty, Siggers, Richard H., Sodhi, Chhinder P., Afrazi, Amin, Alkhudari, Feras, Egan, Charlotte E., Neal, Matthew D., Yazji, Ibrahim, Jia, Hongpeng, Lin, Joyce, Branca, Maria F., Ma, Congrong, Prindle, Thomas, Grant, Zachary, Shah, Sapana, Slagle, Dennis, Paredes, Jose, Ozolek, John, Gittes, George K., Hackam, David J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396489/
https://ncbi.nlm.nih.gov/pubmed/22733781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200856109
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