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Conserved features of intermediates in amyloid assembly determine their benign or toxic states

Some amyloid-forming polypeptides are associated with devastating human diseases and others provide important biological functions. For both, oligomeric intermediates appear during amyloid assembly. Currently we have few tools for characterizing these conformationally labile intermediates and discer...

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Bibliografische gegevens
Hoofdauteurs: Krishnan, Rajaraman, Goodman, Jessica L., Mukhopadhyay, Samrat, Pacheco, Chris D., Lemke, Edward A., Deniz, Ashok A., Lindquist, Susan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396487/
https://ncbi.nlm.nih.gov/pubmed/22745165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1209527109
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