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Chaperone-dependent amyloid assembly protects cells from prion toxicity

Protein conformational diseases are associated with the aberrant accumulation of amyloid protein aggregates, but whether amyloid formation is cytotoxic or protective is unclear. To address this issue, we investigated a normally benign amyloid formed by the yeast prion [RNQ(+)]. Surprisingly, modest...

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Bibliografiska uppgifter
Huvudupphovsmän: Douglas, Peter M., Treusch, Sebastian, Ren, Hong-Yu, Halfmann, Randal, Duennwald, Martin L., Lindquist, Susan, Cyr, Douglas M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2008
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2438228/
https://ncbi.nlm.nih.gov/pubmed/18480252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802593105
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