Derivation Conditions Determine X-Reactivation Status in Female Human Induced Pluripotent Stem Cells

Female human induced pluripotent stem cell (hiPSC) lines exhibit variability in X-inactivation status. The majority of hiPSC lines maintain one transcriptionally active X (Xa) and one inactive X (Xi) chromosome from donor cells. However, at low frequency, hiPSC lines with two Xas are produced, sugge...

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Main Authors: Tomoda, Kiichiro, Takahashi, Kazutoshi, Leung, Karen, Okada, Aki, Narita, Megumi, Yamada, N. Alice, Eilertson, Kirsten E., Tsang, Peter, Baba, Shiro, White, Mark P., Sami, Salma, Srivastava, Deepak, Conklin, Bruce R., Panning, Barbara, Yamanaka, Shinya
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396435/
https://ncbi.nlm.nih.gov/pubmed/22770243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.05.019
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