Comparative dynamic transcriptome analysis (cDTA) reveals mutual feedback between mRNA synthesis and degradation

To monitor eukaryotic mRNA metabolism, we developed comparative dynamic transcriptome analysis (cDTA). cDTA provides absolute rates of mRNA synthesis and decay in Saccharomyces cerevisiae (Sc) cells with the use of Schizosaccharomyces pombe (Sp) as an internal standard. cDTA uses nonperturbing metab...

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Bibliographic Details
Main Authors: Sun, Mai, Schwalb, Björn, Schulz, Daniel, Pirkl, Nicole, Etzold, Stefanie, Larivière, Laurent, Maier, Kerstin C., Seizl, Martin, Tresch, Achim, Cramer, Patrick
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2012
Subjects:
Method
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396375/
https://ncbi.nlm.nih.gov/pubmed/22466169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.130161.111
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