Evaluation of Sulfatase-Directed Quinone Methide Traps for Proteomics

Sulfatases hydrolytically cleave sulfate esters through a unique catalytic aldehyde, which is introduced by a posttranslational oxidation. To profile active sulfatases in health and disease, activity-based proteomic tools are needed. Herein, quinone methide (QM) traps directed against sulfatases are...

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Autori principali: Lenger, Janina, Schröder, Marius, Ennemann, Eva, Müller, Benjamin, Wong, Chi-Huey, Noll, Thomas, Dierks, Thomas, Hanson, Sarah R., Sewald, Norbert
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396293/
https://ncbi.nlm.nih.gov/pubmed/21570853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.04.044
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