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The anticancer activity and cellular repression of c-MYC by the G-quadruplex-stabilizing 11-piperazinyl quindoline is not dependent on direct targeting of the G-quadruplex in the c-MYC promoter

This G-rich region of the c-MYC promoter has been shown to form a G-quadruplex structure, acting as a silencer element for c-MYC transcriptional control. In the present work, we have synthesized a series of 11-substituted quindoline analogs as c-MYC G-quadruplex–stabilizing compounds, and the cell-f...

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Bibliografske podrobnosti
Main Authors: Boddupally, Peda V. L., Hahn, Seongmin, Beman, Cristina, De, Biswanath, Brooks, Tracy A., Gokhale, Vijay, Hurley, Laurence H.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395776/
https://ncbi.nlm.nih.gov/pubmed/22691117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300282c
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