Dissecting a Role of Evolutionary-conserved but Non-critical Disulfide Bridges in Cysteine-Rich Peptides Using ω-Conotoxin GVIA and its Selenocysteine Analogs

Conotoxins comprise a large group of peptidic neurotoxins that employ diverse disulfide-rich scaffolds. Each scaffold is determined by an evolutionarily conserved pattern of cysteine residues. Although many structure-activity relationship studies confirm the functional and structural importance of d...

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Autores principales: Gowd, Konkallu Hanumae, Blais, Kirk D., Elmslie, Keith S., Steiner, Andrew M., Olivera, Baldomero M., Bulaj, Grzegorz
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395435/
https://ncbi.nlm.nih.gov/pubmed/22782563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.22047
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