Sublytic concentrations of Staphylococcus aureus Panton-Valentine leukocidin alter human PMN gene expression and enhance bactericidal capacity

CA-MRSA infections are often caused by strains encoding PVL, which can cause lysis of PMNs and other myeloid cells in vitro, a function considered widely as the primary means by which PVL might contribute to disease. However, at sublytic concentrations, PVL can function as a PMN agonist. To better u...

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Detalhes bibliográficos
Main Authors: Graves, Shawna F., Kobayashi, Scott D., Braughton, Kevin R., Whitney, Adeline R., Sturdevant, Daniel E., Rasmussen, Devon L., Kirpotina, Liliya N., Quinn, Mark T., DeLeo, Frank R.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Leukocyte Biology 2012
Assuntos:
Host Defense & Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395418/
https://ncbi.nlm.nih.gov/pubmed/22581932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1111575
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