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Acute calcineurin inhibition with tacrolimus increases phosphorylated UT-A1
UT-A1, the urea transporter present in the apical membrane of the inner medullary collecting duct, is crucial to the kidney's ability to concentrate urine. Phosphorylation of UT-A1 on serines 486 and 499 is important for plasma membrane trafficking. The effect of calcineurin on dephosphorylatio...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3395357/ https://ncbi.nlm.nih.gov/pubmed/22205230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00358.2011 |
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