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6β-N-Heterocyclic Substituted Naltrexamine Derivative NAP as a Potential Lead to Develop Peripheral Mu Opioid Receptor Selective Antagonists
A 6β-N-heterocyclic substituted naltrexamine derivative, NAP, was proposed as a peripheral mu opioid receptor (MOR) selective antagonist based on the in vitro and in vivo pharmacological and pharmacokinetic studies. To further validate this notion, several functional assays were carried out to fully...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3395321/ https://ncbi.nlm.nih.gov/pubmed/22683223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.05.075 |
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