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Notch and Mef2 synergize to promote proliferation and metastasis through JNK signal activation in Drosophila
Genetic analyses in Drosophila revealed a synergy between Notch and the pleiotropic transcription factor Mef2 (myocyte enhancer factor 2), which profoundly influences proliferation and metastasis. We show that these hyperproliferative and invasive Drosophila phenotypes are attributed to upregulation...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3395089/ https://ncbi.nlm.nih.gov/pubmed/22580825 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.129 |
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