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Hierarchical Phosphorylation of δ-Opioid Receptor Regulates Agonist-induced Receptor Desensitization and Internalization

Treatment of HEK293 cells expressing the δ-opioid receptor with agonist [d-Pen(2,5)]enkephalin (DPDPE) resulted in the rapid phosphorylation of the receptor. We constructed several mutants of the potential phosphorylation sites (Ser/Thr) at the carboxyl tail of the receptor in order to delineate the...

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Bibliografische gegevens
Hoofdauteurs: Maestri-El Kouhen, Odile, Wang, Guilin, Solberg, Jonathan, Erickson, Laurie J., Law, Ping-Yee, Loh, Horace H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2000
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3394401/
https://ncbi.nlm.nih.gov/pubmed/10973976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M006788200
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