Lack of effect of tofacitinib (CP-690,550) on the pharmacokinetics of the CYP3A4 substrate midazolam in healthy volunteers: confirmation of in vitro data

AIMS: To investigate inhibitive and inductive effects of tofacitinib (CP-690,550), a Janus kinase inhibitor, on CYP3A4 function via in vitro and in vivo studies. METHODS: In vitro experiments were conducted to assess the inhibition and induction potential of tofacitinib for major drug metabolizing e...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Gupta, Pankaj, Alvey, Christine, Wang, Rong, Dowty, Martin E, Fahmi, Odette A, Walsky, Robert L, Riese, Richard J, Krishnaswami, Sriram
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Blackwell Science Inc 2012
Aiheet:
Drug Interactions
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3394134/
https://ncbi.nlm.nih.gov/pubmed/22233204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04168.x
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia