Lack of effect of tofacitinib (CP-690,550) on the pharmacokinetics of the CYP3A4 substrate midazolam in healthy volunteers: confirmation of in vitro data

AIMS: To investigate inhibitive and inductive effects of tofacitinib (CP-690,550), a Janus kinase inhibitor, on CYP3A4 function via in vitro and in vivo studies. METHODS: In vitro experiments were conducted to assess the inhibition and induction potential of tofacitinib for major drug metabolizing e...

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Bibliographic Details
Main Authors: Gupta, Pankaj, Alvey, Christine, Wang, Rong, Dowty, Martin E, Fahmi, Odette A, Walsky, Robert L, Riese, Richard J, Krishnaswami, Sriram
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2012
Subjects:
Drug Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3394134/
https://ncbi.nlm.nih.gov/pubmed/22233204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04168.x
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