A clinical study to assess CYP1A2 and CYP3A4 induction by AZD7325, a selective GABA(A) receptor modulator – an in vitro and in vivo comparison

AIM(S): To investigate the potential of AZD7325 to induce CYP1A2 and CYP3A4 enzyme activities. METHODS: Induction of CYP1A2 and CYP3A4 by AZD7325 was first evaluated using cultured human hepatocytes. The effect of multiple doses of 10 mg AZD7325 on the pharmacokinetics of midazolam and caffeine was...

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Detalhes bibliográficos
Main Authors: Zhou, Diansong, Sunzel, Maria, Ribadeneira, Maria D, Smith, Mark A, Desai, Dhaval, Lin, Jianrong, Grimm, Scott W
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2012
Assuntos:
Drug Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3394133/
https://ncbi.nlm.nih.gov/pubmed/22122233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.04155.x
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