A phase I trial of MK-0731, a Kinesin Spindle Protein (KSP) inhibitor, in patients with solid tumors

PURPOSE: The kinesin spindle protein (KSP) is essential for separation of spindle poles during mitosis. Its inhibition results in mitotic arrest. This phase I trial examined safety, tolerability, dose-limiting toxicity (DLT), maximum tolerated dose (MTD), pharmacokinetic parameters, and anti-tumor a...

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Hauptverfasser: Holen, Kyle, DiPaola, Robert, Liu, Glenn, Tan, Antoinette R., Wilding, George, Hsu, Karl, Agrawal, Nancy, Chen, Cong, Xue, Lingling, Rosenberg, Elizabeth, Stein, Mark
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3394096/
https://ncbi.nlm.nih.gov/pubmed/21424701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-011-9653-1
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