A phase I trial of MK-0731, a Kinesin Spindle Protein (KSP) inhibitor, in patients with solid tumors

PURPOSE: The kinesin spindle protein (KSP) is essential for separation of spindle poles during mitosis. Its inhibition results in mitotic arrest. This phase I trial examined safety, tolerability, dose-limiting toxicity (DLT), maximum tolerated dose (MTD), pharmacokinetic parameters, and anti-tumor a...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Main Authors: Holen, Kyle, DiPaola, Robert, Liu, Glenn, Tan, Antoinette R., Wilding, George, Hsu, Karl, Agrawal, Nancy, Chen, Cong, Xue, Lingling, Rosenberg, Elizabeth, Stein, Mark
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2011
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3394096/
https://ncbi.nlm.nih.gov/pubmed/21424701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-011-9653-1
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla