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Extensive Mutagenesis of the Conserved Box E Motif in Duck Hepatitis B Virus P Protein Reveals Multiple Functions in Replication and a Common Structure with the Primer Grip in HIV-1 Reverse Transcriptase

Hepadnaviruses, including the pathogenic hepatitis B virus (HBV), replicate their small DNA genomes through protein-primed reverse transcription, mediated by the terminal protein (TP) domain in their P proteins and an RNA stem-loop, ϵ, on the pregenomic RNA (pgRNA). No direct structural data are ava...

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Autori principali: Wang, Yong-Xiang, Luo, Cheng, Zhao, Dan, Beck, Jürgen, Nassal, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393573/
https://ncbi.nlm.nih.gov/pubmed/22514339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00011-12
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