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Chaperones Activate Hepadnavirus Reverse Transcriptase by Transiently Exposing a C-Proximal Region in the Terminal Protein Domain That Contributes to ɛ RNA Binding

All hepatitis B viruses replicate by protein-primed reverse transcription, employing a specialized reverse transcriptase, P protein, that carries a unique terminal protein (TP) domain. To initiate reverse transcription, P protein must bind to a stem-loop, ɛ, on the pregenomic RNA template. TP then p...

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書目詳細資料
Main Authors: Stahl, Michael, Beck, Jürgen, Nassal, Michael
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168843/
https://ncbi.nlm.nih.gov/pubmed/17913810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01196-07
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