Rifapentine Is Not More Active than Rifampin against Chronic Tuberculosis in Guinea Pigs

Rifamycins are key sterilizing drugs in the current treatment of active tuberculosis (TB). Daily dosing of rifapentine (P), a potent rifamycin with high intracellular accumulation, in place of rifampin (R) in the standard antitubercular regimen significantly shortens the duration of treatment needed...

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Hlavní autoři: Dutta, Noton K., Illei, Peter B., Peloquin, Charles A., Pinn, Michael L., Mdluli, Khisimuzi E., Nuermberger, Eric L., Grosset, Jacques H., Karakousis, Petros C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393407/
https://ncbi.nlm.nih.gov/pubmed/22547623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00500-12
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