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MEK1/2 Inhibition Elicits Regression of Autochthonous Lung Tumors Induced by KRAS(G12D) or BRAF(V600E)
Genetically engineered mouse (GEM) models of lung tumorigenesis allow careful evaluation of lung tumor initiation, progression, and response to therapy. Using GEM models of oncogene-induced lung cancer, we demonstrate the striking similarity of the earliest stages of tumorigenesis induced by KRAS(G1...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3393094/ https://ncbi.nlm.nih.gov/pubmed/22511580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-3649 |
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