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Mutationally activated BRAF(V600E) elicits papillary thyroid cancer in the adult mouse
Mutated BRAF is detected in ~45% of papillary thyroid cancers (PTC). To model PTC, we bred mice with adult-onset, thyrocyte-specific expression of BRAF(V600E). One month following BRAF(V600E) expression, mice displayed increased thyroid size, widespread alterations in thyroid architecture and dramat...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3107361/ https://ncbi.nlm.nih.gov/pubmed/21512141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-4463 |
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