Sialic Acid Deposition Impairs the Utility of AAV9, but Not Peptide-modified AAVs for Brain Gene Therapy in a Mouse Model of Lysosomal Storage Disease

Recombinant vector systems have been recently identified that when delivered systemically can transduce neurons, glia, and endothelia in the central nervous system (CNS), providing an opportunity to develop therapies for diseases affecting the brain without performing direct intracranial injections....

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Bibliografiska uppgifter
Huvudupphovsmän: Chen, Yong Hong, Claflin, Kristin, Geoghegan, James C, Davidson, Beverly L
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2012
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392983/
https://ncbi.nlm.nih.gov/pubmed/22588273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.100
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