Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-Terminal kinase pathway

INTRODUCTION: The c-Jun N-terminal kinase (JNK) is a key regulator of matrix metalloproteinase (MMP) and cytokine production in rheumatoid arthritis (RA) and JNK deficiency markedly protects mice in animal models of arthritis. Cytokine-induced JNK activation is strictly dependent on the mitogen-acti...

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Bibliographic Details
Main Authors: Lee, Sang-il, Boyle, David L, Berdeja, Andres, Firestein, Gary S
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392838/
https://ncbi.nlm.nih.gov/pubmed/22353730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3750
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