c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

Mitogen-activated protein kinase (MAPK) cascades are involved in inflammation and tissue destruction in rheumatoid arthritis (RA). In particular, c-Jun N-terminal kinase (JNK) is highly activated in RA fibroblast-like synoviocytes and synovium. However, defining the precise function of this kinase h...

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Hlavní autoři: Han, Zuoning, Boyle, David L., Chang, Lufen, Bennett, Brydon, Karin, Michael, Yang, Li, Manning, Anthony M., Firestein, Gary S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2001
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC209341/
https://ncbi.nlm.nih.gov/pubmed/11435459
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