A 4-trifluoromethyl analogue of celecoxib inhibits arthritis by suppressing innate immune cell activation

INTRODUCTION: Celecoxib, a highly specific cyclooxygenase-2 (COX-2) inhibitor has been reported to have COX-2-independent immunomodulatory effects. However, celecoxib itself has only mild suppressive effects on arthritis. Recently, we reported that a 4-trifluoromethyl analogue of celecoxib (TFM-C) w...

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Main Authors: Chiba, Asako, Mizuno, Miho, Tomi, Chiharu, Tajima, Ryohsuke, Alloza, Iraide, di Penta, Alessandra, Yamamura, Takashi, Vandenbroeck, Koen, Miyake, Sachiko
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392797/
https://ncbi.nlm.nih.gov/pubmed/22251404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3683
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