Reduced expression of BTBD10, an Akt activator, leads to motor neuron death

BTBD10, an Akt interactor, activates Akt by decreasing the protein phosphatase 2A-mediated dephosphorylation and inactivation of Akt. Overexpression of BTBD10 suppresses motor neuron death that is induced by a familial amyotrophic lateral sclerosis (ALS)-linked superoxide dismutase 1 (SOD1) mutant,...

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Bibliografiske detaljer
Main Authors: Nawa, M, Kage-Nakadai, E, Aiso, S, Okamoto, K, Mitani, S, Matsuoka, M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392628/
https://ncbi.nlm.nih.gov/pubmed/22388351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.19
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