CDK-4 inhibitor P276 sensitizes Pancreatic Cancer cells to Gemcitabine induced Apoptosis

Despite advances in molecular pathogenesis, pancreatic cancer remains a major unsolved health problem. It is a rapidly invasive, metastatic tumor that is resistant to standard therapies. The phosphatidylinositol-3-kinase (PI3K)/Akt and mammalian target of rapamycin (mTOR) signaling pathways are freq...

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Main Authors: Subramaniam, Dharmalingam, Periyasamy, Giridharan, Ponnurangam, Sivapriya, Chakrabarti, Debarshi, Sugumar, Aravind, Padigaru, Muralidhara, Weir, Scott J., Balakrishnan, Arun, Sharma, Somesh, Anant, Shrikant
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392497/
https://ncbi.nlm.nih.gov/pubmed/22532602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0102
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