MIP-1δ Activates NFATc1 and Enhances Osteoclastogenesis: Involvement of Both PLCγ2 and NFκB Signaling

Pathological bone resorption is a source of significant morbidity in diseases affecting the skeleton such as rheumatoid arthritis, periodontitis, and cancer metastasis to bone. Evidence indicates that elevated levels of inflammatory mediators such as IL-1, IL-6, and TNF-α play a role in this process...

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Bibliografiska uppgifter
Huvudupphovsmän: Weber, Kristy L., Doucet, Michele, Shaner, Adam, Hsu, Nigel, Huang, David, Fogel, Jenna, Kominsky, Scott L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2012
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392212/
https://ncbi.nlm.nih.gov/pubmed/22792407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040799
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