Age-Related Instability in Spermatogenic Cell Nuclear and Mitochondrial DNA Obtained from Apex1 Heterozygous Mice

The prevalence of spontaneous mutations increases with age in the male germline; consequently, older men have an increased risk of siring children with genetic disease due to de novo mutations. The lacI transgenic mouse can be used to study paternal age effects, and in this system, the prevalence of...

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Autori principali: Vogel, Kristine S., Perez, Marissa, Momand, Jamila R., Acevedo-Torres, Karina, Hildreth, Kim, Garcia, Rebecca A., Torres-Ramos, Carlos A., Ayala-Torres, Sylvette, Prihoda, Thomas J., McMahan, C. Alex, Walter, Christi A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391697/
https://ncbi.nlm.nih.gov/pubmed/21919107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mrd.21374
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