Age-Related Instability in Spermatogenic Cell Nuclear and Mitochondrial DNA Obtained from Apex1 Heterozygous Mice

The prevalence of spontaneous mutations increases with age in the male germline; consequently, older men have an increased risk of siring children with genetic disease due to de novo mutations. The lacI transgenic mouse can be used to study paternal age effects, and in this system, the prevalence of...

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Autors principals: Vogel, Kristine S., Perez, Marissa, Momand, Jamila R., Acevedo-Torres, Karina, Hildreth, Kim, Garcia, Rebecca A., Torres-Ramos, Carlos A., Ayala-Torres, Sylvette, Prihoda, Thomas J., McMahan, C. Alex, Walter, Christi A.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391697/
https://ncbi.nlm.nih.gov/pubmed/21919107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mrd.21374
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