Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast

BACKGROUND: Organisms use highly accurate molecular processes to transcribe their genes and a variety of mRNA quality control and ribosome proofreading mechanisms to maintain intact the fidelity of genetic information flow. Despite this, low level gene translational errors induced by mutations and e...

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Main Authors: Paredes, João A, Carreto, Laura, Simões, João, Bezerra, Ana R, Gomes, Ana C, Santamaria, Rodrigo, Kapushesky, Misha, Moura, Gabriela R, Santos, Manuel AS
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391182/
https://ncbi.nlm.nih.gov/pubmed/22715922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-10-55
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