Interplay between T Cell Receptor Binding Kinetics and the Level of Cognate Peptide Presented by Major Histocompatibility Complexes Governs CD8(+) T Cell Responsiveness

Through a rational design approach, we generated a panel of HLA-A*0201/NY-ESO-1(157–165)-specific T cell receptors (TCR) with increasing affinities of up to 150-fold from the wild-type TCR. Using these TCR variants which extend just beyond the natural affinity range, along with an extreme supraphysi...

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Autori principali: Irving, Melita, Zoete, Vincent, Hebeisen, Michael, Schmid, Daphné, Baumgartner, Petra, Guillaume, Philippe, Romero, Pedro, Speiser, Daniel, Luescher, Immanuel, Rufer, Nathalie, Michielin, Olivier
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391157/
https://ncbi.nlm.nih.gov/pubmed/22549784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.357673
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