Protein Inhibitor of Activated STAT3 (PIAS3) Protein Promotes SUMOylation and Nuclear Sequestration of the Intracellular Domain of ErbB4 Protein

ErbB4 is a receptor tyrosine kinase implicated in the development and homeostasis of the heart, central nervous system, and mammary gland. Cleavable isoforms of ErbB4 release a soluble intracellular domain (ICD) that can translocate to the nucleus and function as a transcriptional coregulator. In se...

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Bibliographische Detailangaben
Hauptverfasser: Sundvall, Maria, Korhonen, Anna, Vaparanta, Katri, Anckar, Julius, Halkilahti, Kalle, Salah, Zaidoun, Aqeilan, Rami I., Palvimo, Jorma J., Sistonen, Lea, Elenius, Klaus
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391121/
https://ncbi.nlm.nih.gov/pubmed/22584572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.335927
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