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Opposing Roles for TRAF1 in the Alternative versus Classical NF-κB Pathway in T Cells
T cells lacking TRAF1 hyperproliferate in response to T cell receptor signaling but have impaired signaling downstream of specific TNFR family members such as 4-1BB. Here we resolve this paradox by showing that while TRAF1 is required for maximal activation of the classical NF-κB pathway downstream...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Biochemistry and Molecular Biology
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3391120/ https://ncbi.nlm.nih.gov/pubmed/22570473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.350538 |
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