The Tumor Suppressor DiRas3 Forms a Complex with H-Ras and C-RAF Proteins and Regulates Localization, Dimerization, and Kinase Activity of C-RAF

The maternally imprinted Ras-related tumor suppressor gene DiRas3 is lost or down-regulated in more than 60% of ovarian and breast cancers. The anti-tumorigenic effect of DiRas3 is achieved through several mechanisms, including inhibition of cell proliferation, motility, and invasion, as well as ind...

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Bibliographic Details
Main Authors: Baljuls, Angela, Beck, Matthias, Oenel, Ayla, Robubi, Armin, Kroschewski, Ruth, Hekman, Mirko, Rudel, Thomas, Rapp, Ulf R.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391090/
https://ncbi.nlm.nih.gov/pubmed/22605333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.343780
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