IQGAP Proteins Reveal an Atypical Phosphoinositide (aPI) Binding Domain with a Pseudo C2 Domain Fold

Class I phosphoinositide (PI) 3-kinases act through effector proteins whose 3-PI selectivity is mediated by a limited repertoire of structurally defined, lipid recognition domains. We describe here the lipid preferences and crystal structure of a new class of PI binding modules exemplified by select...

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Detalhes bibliográficos
Main Authors: Dixon, Miles J., Gray, Alexander, Schenning, Martijn, Agacan, Mark, Tempel, Wolfram, Tong, Yufeng, Nedyalkova, Lyudmila, Park, Hee-Won, Leslie, Nicholas R., van Aalten, Daan M. F., Downes, C. Peter, Batty, Ian H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391087/
https://ncbi.nlm.nih.gov/pubmed/22493426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.352773
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