Homeostatic Synaptic Scaling Is Regulated by Protein SUMOylation

Homeostatic scaling allows neurons to alter synaptic transmission to compensate for changes in network activity. Here, we show that suppression of network activity with tetrodotoxin, which increases surface expression of AMPA receptors (AMPARs), dramatically reduces levels of the deSUMOylating (wher...

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Detalles Bibliográficos
Main Authors: Craig, Tim J., Jaafari, Nadia, Petrovic, Milos M., Rubin, Philip P., Mellor, Jack R., Henley, Jeremy M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Neurobiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391081/
https://ncbi.nlm.nih.gov/pubmed/22582390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.356337
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