Role of Metal Ions on the Activity of Mycobacterium tuberculosis Pyrazinamidase

Pyrazinamidase of Mycobacterium tuberculosis catalyzes the conversion of pyrazinamide to the active molecule pyrazinoic acid. Reduction of pyrazinamidase activity results in a level of pyrazinamide resistance. Previous studies have suggested that pyrazinamidase has a metal-binding site and that a di...

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Autori principali: Sheen, Patricia, Ferrer, Patricia, Gilman, Robert H., Christiansen, Gina, Moreno-Román, Paola, Gutiérrez, Andrés H., Sotelo, Jun, Evangelista, Wilfredo, Fuentes, Patricia, Rueda, Daniel, Flores, Myra, Olivera, Paula, Solis, José, Pesaresi, Alessandro, Lamba, Doriano, Zimic, Mirko
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society of Tropical Medicine and Hygiene 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391041/
https://ncbi.nlm.nih.gov/pubmed/22764307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4269/ajtmh.2012.10-0565
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