Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogs with improved tissue penetration and hypoxic cell killing in tumors

PURPOSE: Tirapazamine (TPZ) has attractive features for targeting hypoxic cells in tumors but limited clinical activity, in part because of poor extravascular penetration. Here we identify improved TPZ analogs by using a spatially resolved pharmacokinetic/pharmacodynamic (SR-PKPD) model that conside...

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Bibliographic Details
Main Authors: Hicks, Kevin O., Siim, Bronwyn G., Jaiswal, Jagdish K., Pruijn, Frederik B., Fraser, Annie M., Patel, Rita, Hogg, Alison, Liyanage, H.D. Sarath, Jo Dorie, Mary, Brown, J. Martin, Denny, William. A., Hay, Michael P., Wilson, William R.
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390971/
https://ncbi.nlm.nih.gov/pubmed/20732963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-1439
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