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Epitope targeting and viral inoculum are determinants of Nef-mediated immune evasion of HIV-1 from cytotoxic T lymphocytes

The impact of HIV-1 Nef-mediated HLA-I down-regulation on CD8(+) cytotoxic T lymphocytes (CTLs) varies by epitope, but the determining factors have not been elucidated. In the present study, we investigated the impact of Nef on the antiviral efficiency of HIV-1–specific CTLs targeting 17 different e...

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Bibliografiske detaljer
Main Authors: Chen, Diana Y., Balamurugan, Arumugam, Ng, Hwee L., Cumberland, William G., Yang, Otto O.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390950/
https://ncbi.nlm.nih.gov/pubmed/22613796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-02-409870
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