Unexpected tautomeric equilibria of the carbanion-enamine intermediate in pyruvate oxidase highlight unrecognized chemical versatility of thiamin

Thiamin diphosphate, the vitamin B1 coenzyme, plays critical roles in fundamental metabolic pathways that require acyl carbanion equivalents. Studies on chemical models and enzymes had suggested that these carbanions are resonance-stabilized as enamines. A crystal structure of this intermediate in p...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Meyer, Danilo, Neumann, Piotr, Koers, Eline, Sjuts, Hanno, Lüdtke, Stefan, Sheldrick, George M., Ficner, Ralf, Tittmann, Kai
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2012
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390845/
https://ncbi.nlm.nih.gov/pubmed/22730460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201280109
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