Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes

African trypanosomes cause sleeping sickness in humans, a disease that is typically fatal without chemotherapy. Unfortunately, drug resistance is common and melarsoprol-resistant trypanosomes often display cross-resistance to pentamidine. Although melarsoprol/pentamidine cross-resistance (MPXR) has...

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Main Authors: Baker, Nicola, Glover, Lucy, Munday, Jane C., Aguinaga Andrés, David, Barrett, Michael P., de Koning, Harry P., Horn, David
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2012
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390834/
https://ncbi.nlm.nih.gov/pubmed/22711816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202885109
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