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Human POLB Gene Is Mutated in High Percentage of Colorectal Tumors
Previous small scale sequencing studies have indicated that DNA polymerase β (pol β) variants are present on average in 30% of human tumors of varying tissue origin. Many of these variants have been shown to have aberrant enzyme function in vitro and to induce cellular transformation and/or genomic...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3390656/ https://ncbi.nlm.nih.gov/pubmed/22577134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.324947 |
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