Human POLB Gene Is Mutated in High Percentage of Colorectal Tumors

Previous small scale sequencing studies have indicated that DNA polymerase β (pol β) variants are present on average in 30% of human tumors of varying tissue origin. Many of these variants have been shown to have aberrant enzyme function in vitro and to induce cellular transformation and/or genomic...

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Autori principali: Donigan, Katherine A., Sun, Ka-wai, Nemec, Antonia A., Murphy, Drew L., Cong, Xiangyu, Northrup, Veronika, Zelterman, Daniel, Sweasy, Joann B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
Soggetti:
DNA and Chromosomes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390656/
https://ncbi.nlm.nih.gov/pubmed/22577134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.324947
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