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Sequestration of Sup35 by Aggregates of huntingtin Fragments Causes Toxicity of [PSI(+)] Yeast
Expression of huntingtin fragments with 103 glutamines (HttQ103) is toxic in yeast containing either the [PIN(+)] prion, which is the amyloid form of Rnq1, or [PSI(+)] prion, which is the amyloid form of Sup35. We find that HttQP103, which has a polyproline region at the C-terminal end of the polyQ...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3390612/ https://ncbi.nlm.nih.gov/pubmed/22573320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.287748 |
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