Structural Characterization of Binding Mode of Smoking Cessation Drugs to Nicotinic Acetylcholine Receptors through Study of Ligand Complexes with Acetylcholine-binding Protein

Smoking cessation is an important aim in public health worldwide as tobacco smoking causes many preventable deaths. Addiction to tobacco smoking results from the binding of nicotine to nicotinic acetylcholine receptors (nAChRs) in the brain, in particular the α4β2 receptor. One way to aid smoking ce...

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Detalhes bibliográficos
Main Authors: Rucktooa, Prakash, Haseler, Claire A., van Elk, René, Smit, August B., Gallagher, Timothy, Sixma, Titia K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390607/
https://ncbi.nlm.nih.gov/pubmed/22553201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.360347
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