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Structural Characterization of Binding Mode of Smoking Cessation Drugs to Nicotinic Acetylcholine Receptors through Study of Ligand Complexes with Acetylcholine-binding Protein

Smoking cessation is an important aim in public health worldwide as tobacco smoking causes many preventable deaths. Addiction to tobacco smoking results from the binding of nicotine to nicotinic acetylcholine receptors (nAChRs) in the brain, in particular the α4β2 receptor. One way to aid smoking ce...

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Main Authors: Rucktooa, Prakash, Haseler, Claire A., van Elk, René, Smit, August B., Gallagher, Timothy, Sixma, Titia K.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390607/
https://ncbi.nlm.nih.gov/pubmed/22553201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.360347
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