Importance of SPP1 genotype as a covariate in clinical trials in Duchenne muscular dystrophy

OBJECTIVE: To test the effect of the single nucleotide polymorphism −66 T>G (rs28357094) in the osteopontin gene (SPP1) on functional measures over 12 months in Duchenne muscular dystrophy (DMD). METHODS: This study was conducted on a cohort of ambulatory patients with DMD from a network of Itali...

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Main Authors: Bello, Luca, Piva, Luisa, Barp, Andrea, Taglia, Antonella, Picillo, Esther, Vasco, Gessica, Pane, Marika, Previtali, Stefano C., Torrente, Yvan, Gazzerro, Elisabetta, Chiara Motta, Maria, Grieco, Gaetano S., Napolitano, Sara, Magri, Francesca, D'Amico, Adele, Astrea, Guja, Messina, Sonia, Sframeli, Maria, Luca Vita, Gian, Boffi, Patrizia, Mongini, Tiziana, Ferlini, Alessandra, Gualandi, Francesca, Soraru', Gianni, Ermani, Mario, Vita, Giuseppe, Battini, Roberta, Bertini, Enrico, Comi, Giacomo P., Berardinelli, Angela, Minetti, Carlo, Bruno, Claudio, Mercuri, Eugenio, Politano, Luisa, Angelini, Corrado, Hoffman, Eric P., Pegoraro, Elena
Format: Artigo
Jezik:Inglês
Izdano: Lippincott Williams & Wilkins 2012
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390537/
https://ncbi.nlm.nih.gov/pubmed/22744661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e31825f04ea
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